This study compared the shear bond strengths (SBS) to dentin achieved with six self-etching systems and one total-etch one-bottle adhesive system. Seventy freshly extracted bovine incisors were mounted in acrylic molds and the facial surfaces ground to expose middle dentin, which was polished by 600-grit sand paper. The incisors were randomly assigned to groups (n=10): Adper Prompt Self-Etch Adhesive, 3M-ESPE (ADP) and One-Up Bond F, Tokuyama (OU) as self-etching adhesives; AdheSE, Ivoclar-Vivadent (ADH), Clearfil SE Bond, Kuraray (SE), Optibond Solo Plus-Self-Etch, Kerr (OP) as self-etching primers, Tyrian SPE, BISCO (TY) as a self-priming etchant and Single Bond, 3M-ESPE (SB), a total-etch one-bottle adhesive served as a control. All adhesives were applied according to the manufacturers' instructions with the respective hybrid composites. The specimens were thermocycled for 500 cycles (5 degrees C to 55 degrees C), then loaded to failure in an Instron Universal Testing Machine at a crosshead speed of 0.5 mm/minute. Mean bond strengths were analyzed with one-way ANOVA, followed by a Duncan's post hoc test. SBS (mean +/- SD) were: ADH = 13.2 (+/- 5.3)b;ADP = 6.8 (+/- 4.4)c; OP = 18.2 (+/- 3.8)a; OU = 3.5 (+/- 1.5)c; SB = 12.2 (+/- 4.2)b; SE = 12.4 ( +/- 4.0)b; TY = 5.5 (+/- 1.4)c. Superscript letters indicate Duncan's homogeneous subsets. The self-etching adhesives OU and ADP and the self-priming etchant TY resulted in lower dentin SBS. OP resulted in the highest mean dentin SBS, while the other materials tested in this study (SE and ADH) presented similar dentin SBS to a total-etch one-bottle bonding system (SB).